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Symbol
Name
ID

Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
MGI:104741

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgG level

Polyclonal elevation of IgM

Decreased circulating antibody level

Paraproteinemia

Impaired lymphocyte transformation with phytohemagglutinin

Lymphadenopathy

Splenomegaly

Recurrent infection of the gastrointestinal tract

Subacute progressive viral hepatitis

Defective production of NFKB1-dependent cytokines

Recurrent respiratory infections

Disease(s) Associated with NFKBIA

ectodermal dysplasia and immunodeficiency 2

hepatocellular carcinoma

Hodgkin's lymphoma

multiple myeloma

Mouse Phenotypes

increased activation-induced B cell apoptosis

increased T cell apoptosis

abnormal granulocyte differentiation

decreased B cell proliferation

increased B cell proliferation

decreased T cell proliferation

increased T cell proliferation

thymus atrophy

decreased thymocyte number

increased thymocyte number

abnormal B cell differentiation

decreased transitional stage T2 B cell number

increased immature B cell number

increased pro-B cell number

decreased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

abnormal myelopoiesis

abnormal granulocyte morphology

increased granulocyte number

decreased mature B cell number

decreased B-2 B cell number

decreased follicular B cell number

decreased marginal zone B cell number

decreased B cell number

increased pre-B cell number

abnormal T cell number

decreased CD4-positive, alpha-beta memory T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased memory T cell number

decreased regulatory T cell number

increased activated T cell number

increased single-positive T cell number

increased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

abnormal marginal zone B cell morphology

small spleen

spleen atrophy

absent spleen germinal center

decreased IgA level

increased IgA level

increased IgE level

decreased IgG1 level

decreased IgG2b level

increased IgG level

abnormal T cell activation

abnormal macrophage physiology

abnormal circulating cytokine level

increased circulating interleukin-1 alpha level

increased circulating interleukin-17 level

increased circulating tumor necrosis factor level

abnormal tumor necrosis factor level

decreased Peyer's patch number

small Peyer's patches

abnormal humoral immune response

autoimmune response

increased anti-insulin autoantibody level

increased anti-nuclear antigen antibody level

chronic inflammation

dermatitis

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Nfkbia^tm1.1Kbp/Nfkbia^tm1.1Kbp

Nfkbia^tm1.1Pjc/Nfkbia^tm1.1Pjc

Nfkbia^tm1.1Smiy/Nfkbia^tm1.1Smiy

Nfkbia^tm1Bal/Nfkbia^tm1Bal

Nfkbia^tm1Fey/Nfkbia^tm1Fey

Nfkbia^tm1Stw/Nfkbia^tm1Stw

Nfkbia^tm1.1Smiy/Nfkbia⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23